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目的:牵张成骨广泛用于治疗骨发育不足以及骨缺损等方面,该方式的短期效果及原理研究较为广泛,但长期应用效果以及机理等理论依据较为缺乏。该实验研究牵张成骨后周围软组织长时期血管变化关系,进一步丰富牵张成骨的理论依据。方法:对10只成年绵羊的单侧下颌骨进行截断轴向牵拉延长,截骨位置位于左侧下颌升支前缘,咬肌附着处。在颌骨截断后的一周,我们对它进行牵拉延长,持续10天;在此之后对牵拉成果进行巩固,为期60天。然后处死实验动物,对软硬组织进行放射性粒子示踪,血流量分析。结果:无论软硬组织,牵张侧血流量均优于对照侧。结论:牵张成骨可以促进血管发生,并且维持血管的生成直至固定晚期。
OBJECTIVE: Distraction osteogenesis is widely used in the treatment of bone defects and bone defects. The short-term effects and principles of this method are extensively studied. However, the theoretical basis of long-term application effects and mechanism is relatively scarce. This experimental study disturbs the long-term vascular changes in the surrounding soft tissue after osteogenesis to further enrich the theoretical basis for distraction osteogenesis. Methods: Unilateral mandibular mandibular mandibular traction was performed in 10 adult sheep. The osteotomy site was located on the leading edge of the ascending ramus of the left mandible and attached to the masseter muscle. In the week after the jaws were cut off, we stretched it for 10 days; afterwards we consolidated the results of the pull for 60 days. Then sacrifice experimental animals, radioactive particle tracing of soft and hard tissue, blood flow analysis. Results: No matter soft or hard tissue, distraction side blood flow was better than the control side. Conclusion: Distraction osteogenesis can promote angiogenesis, and maintain the formation of blood vessels until the late stage of fixation.