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表观遗传(epigenetics)是指DNA序列不发生变化,但基因表达却发生了可遗传的改变。在细胞分裂时,表观遗传能影响正常基因的遗传表型,从而影响疾病发生。糖尿病是当今严重危害人类健康的疾病之一,许多营养物质与其发生有关系,其中,一些植物化学物能通过表观遗传机制影响糖尿病及其并发症的发生。本文就近年来与糖尿病有关的表观遗传机制的研究及与之有关的植物化学物的研究进展做一综述。
Epigenetics refers to the fact that DNA sequences do not change, but gene expression is genetically altered. Epigenetics can affect the genetic phenotype of normal genes during cell division, thus affecting the disease. Diabetes is one of the most serious diseases that endanger human health. Many nutrients are involved in the pathogenesis of diabetes. Some of the phytochemicals affect the development of diabetes mellitus and its complications via epigenetic mechanisms. This review summarizes the recent studies on the epigenetic mechanisms associated with diabetes and related phytochemicals.