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目的：探讨慢性心衰时心肌细胞肌动蛋白的变化情况。方法：采用ＳＰ免疫组化方法，对升主动脉缩窄慢性心衰大鼠心肌细胞肌动蛋白进行定性及半定量分析。结果：慢性心衰时左心室心肌细胞肌动蛋白免疫反应活性显著降低，反应产物排列不规则，而右心室心肌细胞肌动蛋白免疫反应活性无显著变化。结论：肌动蛋白活性降低是引起收心肌收缩力降低的原因之一。
Objective: To investigate the changes of actin in cardiomyocytes during chronic heart failure. Methods: SP immunohistochemical method was used to qualitative and semi-quantitative analysis of myocardial actin in rat with ascending aortic constriction chronic heart failure. Results: The activities of actin immunoreactivity in left ventricular myocardium were significantly decreased, the reaction products were irregularly arranged, and the actin immunoreactivity in right ventricular myocardium was not significantly changed. Conclusion: The decrease of actin activity is one of the reasons for the decrease of contractility of myocardium.