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目的比较不同剂量地佐辛复合依托咪酯乳剂在无痛人工流产术中的应用效果。方法选取桂林医学院附属医院2015年12月—2016年12月收治的行无痛人工流产手术患者148例,按照随机数字表法分为D0、D1、D2、D3组,各37例。D0组应用依托咪酯乳剂,D1组应用依托咪酯乳剂复合地佐辛20μg/kg,D2组应用依托咪酯乳剂复合地佐辛40μg/kg,D3组应用依托咪酯乳剂复合地佐辛60μg/kg。比较4组患者麻醉苏醒时间,麻醉前、麻醉后、手术前、手术后脉搏、血氧饱和度、平均动脉压,不良反应、追加药物率及满意度。结果 4组患者苏醒时间比较,差异有统计学意义(P<0.05);D2组苏醒时间短于D0、D1、D3组(P<0.05);其他各组组间比较,差异无统计学意义(P>0.05)。麻醉前、麻醉后、手术前、手术后4组患者脉搏、血氧饱和度、平均动脉压比较,差异无统计学意义(P>0.05)。4组患者不良反应发生率、追加药物率及满意度比较,差异有统计学意义(P<0.05);D2组不良反应发生率低于D0组,追加药物率低于D0、D1、D3组,满意度高于D0、D1、D3组(P<0.05)。结论依托咪酯乳剂复合40μg/kg地佐辛应用于无痛人工流产术中效果更好,其具有手术过程患者生命体征更平稳、苏醒时间短、术后不良反应少、患者满意度高等优势。
Objective To compare the effects of different doses of dezocine combined with etomidate emulsion in painless artificial abortion. Methods A total of 148 patients undergoing painless induced abortion were enrolled in the Affiliated Hospital of Guilin Medical College from December 2015 to December 2016, and divided into D0, D1, D2 and D3 groups according to the random number table. Group D0 etomidate emulsion, group D1 etomidate emulsion compound zizoxin 20μg / kg, group D2 etomidate emulsion compound zizoxin 40μg / kg, group D3 etomidate emulsion compound zizoxin 60μg / kg. The anesthesia recovery time, anesthesia, anesthesia, preoperative, postoperative pulse, oxygen saturation, mean arterial pressure, adverse reactions, additional drug rates and satisfaction were compared between the 4 groups. Results Compared with D0, D1 and D3 groups (P <0.05), awake time in D2 group was significantly higher than that in D0 group (P <0.05). There were no significant differences among the other groups P> 0.05). Before anesthesia, anesthesia, preoperative and postoperative 4 groups of patients with pulse, oxygen saturation, mean arterial pressure, the difference was not statistically significant (P> 0.05). Adverse drug reaction rate, additional drug rate and satisfaction in 4 groups were significantly different (P <0.05). The incidence of adverse reactions in D2 group was lower than that in D0 group and the additional drug rates were lower than those in D0, D1 and D3 groups Satisfaction was higher than D0, D1, D3 (P <0.05). Conclusion Etomidate emulsion 40μg / kg dezocine combined with painless artificial abortion is more effective. It has the advantages of stable vital signs, short recovery time, fewer adverse reactions and higher patient satisfaction.