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目的探讨多发性硬化(MS)的临床特点。方法综合分析168例多发性硬化患者的一般资料、病变部位、重要辅助检查及治疗方法。结果168例MS患者最常见的临床症状为肢体无力和感觉异常,其次为肌肉痉挛性疼痛、视力障碍、排便异常、共济失调,个别患者可有周围神经改变。实验室检查示:脑脊液蛋白水平和IgG指数增高最常见。磁共振(MR I)异常率高达90.98%。糖皮质激素治疗有效。结论MS是一种临床表现复杂、累及中枢神经系统白质多部位、病程表现多时相的自身免疫性疾病。根据临床特点,综合神经电生理、脑脊液免疫学及影像学检查能大大提高临床确诊率,其中磁共振成像意义较大。
Objective To investigate the clinical features of multiple sclerosis (MS). Methods A total of 168 cases of multiple sclerosis patients with general information, lesions, important auxiliary examination and treatment. Results The most common clinical symptoms of 168 MS patients were limb weakness and sensory abnormalities, followed by muscle spasmodic pain, visual impairment, defecation abnormalities and ataxia. Individual patients may have peripheral nerve changes. Laboratory tests show: cerebrospinal fluid protein levels and IgG index is the most common. Magnetic resonance (MR I) abnormal rate as high as 90.98%. Glucocorticoid treatment is effective. Conclusion MS is a kind of autoimmune disease with complicated clinical manifestations and involving in multiple sites of the white matter of the central nervous system, with a multi-temporal appearance. According to clinical features, comprehensive neuroelectrophysiology, cerebrospinal fluid immunology and imaging examination can greatly improve the clinical diagnosis rate, in which magnetic resonance imaging is of great significance.