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目的 :观察羟基喜树碱治疗恶性胸腹腔积液的临床疗效与毒副作用。方法 :2 3例恶性胸腹腔积液常规胸腔抽液或腹穿引流后 ,腔内注入羟基喜树碱 3 0mg/次 ,每周 1次 ,连续 2～ 3次为 1个疗程。结果 :完全缓解 13例 (5 6.5 2 % ) ,部分缓解 8例 (3 7.7% ) ,无效 2例 (8.19% ) ,总有效 2 1例 (91.3 % )。毒副作用为消化道反应共 2例 (8.19% )。结论 :羟基喜树碱腔内灌注治疗恶性胸腹腔积液 ,疗效好、毒副作用轻微、方法简单
Objective: To observe the clinical efficacy and side effects of hydroxycamptothecin in the treatment of malignant pleural and peritoneal effusion. Methods: Twenty-three patients with malignant pleural effusion and pleural effusion were routinely treated with thoracic fluid ablation or abdominal drainage. The cavity was infused with 30 mg of hydroxycamptothecine once a week for 2 to 3 consecutive times. Results: Complete remission was achieved in 13 cases (5 6.52%), partial remission in 8 cases (3 7.7%), ineffective in 2 cases (8.19%) and total effective response in 21 cases (91.3%). Toxic side effects of gastrointestinal reactions in 2 cases (8.19%). Conclusion: HCPT for the treatment of malignant pleural and peritoneal effusion has good curative effect, mild side effects and simple method