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目的:评价经胃左动脉化疗与栓塞对贲门癌的疗效。对象与方法:44例经胃镜检查和病理证实的中、晚期贲门癌患者(含术后复发6例)均经胃左动脉灌注化疗(ADM+MMC+5Fu或DDP+MMC+ADM)1～3次,其中12例还经栓塞治疗。结果:按全国胃癌协作组推荐“进展期胃癌全身化疗判定标准”,本组病例中,完全缓解即病变缩小70％以上伴症状明显改善者18例,部分缓解即病变缩小50％左右伴症状明显改善者19例,以及稳定即病变缩小25％以下伴症状轻微改善者7例。除9例死于化疗后第4～22个月(中位存活期13.2个月)外,其余35例至今仍生存,有的存活期已达30个月。在5例化疗后接受手术根治的患者中,术中发现比未经该化疗者的肿瘤界限较清晰,易剥离,出血少,而且部分已纤维化。结论:经胃左动脉化疗与栓塞对中、晚期贲门癌具有非常卓越的疗效。
Objective: To evaluate the effect of transarterial left arterial chemotherapy and embolization on cardia cancer. Subjects and Methods: Forty-four patients with middle and advanced cardia cancer confirmed by gastroscopy and pathology (including 6 cases with postoperative recurrence) were treated by gastric left arterial infusion chemotherapy (ADM + MMC + 5Fu or DDP + MMC + ADM) Times, of which 12 cases were also embolized. Results: According to the National Gastric Cancer Group recommended “advanced gastric cancer chemotherapy criteria,” this group of patients, complete remission that lessened more than 70% with significant improvement in 18 cases, partial relief that lessened about 50% of patients with obvious symptoms Improvement in 19 cases, and the stability of the lesion is reduced by 25% with slight improvement in 7 cases. Except for 9 cases who died from the 4th to 22th month after chemotherapy (median survival was 13.2 months), the remaining 35 cases still survived till now and some had survived for 30 months. Of the 5 patients who underwent radical surgery after surgery, there was a clear, easy-to-peel, less bleeding and some fibrosis in the surgery than those without the tumor. Conclusion: The transgastric arterial chemoembolization and embolization have a very good curative effect on middle and advanced gastric cardia carcinoma.