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以脱镁叶绿酸-a甲酯为起始原料,利用C-吡咯子环所连带的活性反应区域进行空气氧化、与甲醛的羟醛缩合、环酮的亲核加成以及与重氮甲烷的Tiffeneau-demjanov重排等化学反应,在五元外接环和12-位上建立了不同的羰基结构.新形成的活性基团与邻苯二胺、邻氨基苯甲醛的缩合,与甲醛和肌氨酸的1,3-偶极环加成以及其他结构转换,在外接环上和12-位上形成包括含氮杂环和螺环在内的新颖结构,完成了一系列未见报道的叶绿素类二氢卟吩衍生物的合成,其化学结构均经UV、IR、1H NMR及元素分析予以证实.
Pheophorbide-a methyl ester as a starting material, the use of C-pyrrole ring associated with the active reaction zone for air oxidation, with the aldol formaldehyde condensation nucleophilic addition of cyclic ketone and diazomethane Tiffeneau-demjanov rearrangement and other chemical reactions in the five yuan external ring and 12-position to establish a different carbonyl structure. The newly formed active groups with o-phenylenediamine, o-aminobenzaldehyde condensation, and formaldehyde and muscle 1,3-dipolar cycloaddition of amino acids and other structural transitions to form novel structures including nitrogen-containing heterocycles and spirocycles on the exocyclic ring and the 12-position, completing a series of unreported chlorophyll The chemical structure of the class of chlorin derivatives was confirmed by UV, IR, 1H NMR and elemental analysis.