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近年来发现了若干与脑外伤预后密切相关的基因,包括白介素-1(IL-1)家族的IL-1A、IL-1B及IL-1RN基因、载脂蛋白E(APOE)基因、多巴胺D2受体(DRD2)基因、儿茶酚胺-o-甲基转移酶(COMT)基因、血管紧张素转换酶(ACE)基因及p5 3基因。它们分别从外伤后炎症反应的发生和发展;中枢神经系统中脂质及淀粉样蛋白的转运和沉积;与多巴胺能系统有关的认知功能的改变;脑血管的自动调节功能及细胞凋亡等不同方面来影响脑外伤的进程和转归。充分认识这些基因多态性与脑外伤预后的关系,为该疾病的治疗提供了新思路、新方法。
Several genes closely related to the prognosis of brain trauma have been found in recent years, including IL-1A, IL-1B and IL-1RN genes of the interleukin-1 (IL-1) family, apolipoprotein E (APOE) (DRD2), catecholamine-o-methyltransferase (COMT) gene, angiotensin-converting enzyme (ACE) gene and p5 3 gene. They are respectively from the occurrence and development of post-traumatic inflammatory response; transport and deposition of lipid and amyloid in the central nervous system; changes in cognitive function associated with the dopaminergic system; autoregulation of cerebrovascular and apoptosis Different aspects to affect the process and outcome of traumatic brain injury. Fully understanding the relationship between these gene polymorphisms and the prognosis of traumatic brain injury provides new ideas and new methods for the treatment of this disease.