论文部分内容阅读
雾化的溴化异丙托品是一种支气管扩张剂,是一种对急性哮喘很有价值的药物。但亦有持相反意见者,认为此为低渗溶液,可引起支气管收缩,因此,配制成含有防腐剂氯化苯甲烃铵和依地酸(EDTA)的等渗溶液应用。本研究目的就是比较含防腐剂的溴化异丙托品(PCIB)和不含防腐剂的溴化异丙托品(PFIB)二种溶液的疗效。方法选择33名哮喘患儿(男21名),平均年龄11.4岁,患儿都熟悉操作呼吸量测定法。至少在先前12个月中,经支气管扩张剂吸入后改善15%以上的一秒钟用力呼气量(FEV_1)。28名儿童吸入类固醇,3名吸入色甘酸钠和/或4名口服类固醇。他们曾有规律地或必要时使用各种β-兴奋剂、茶硷和溴化异丙托品。分二天进行肺功能测定,研究前至少停用β-兴奋剂和抗胆硷能药物4小时或茶硷12小时。用Gould 充水呼吸量测定仪获得FEV_1和25～75%间强迫肺活量的强迫呼气量(FEF_(25-75)),并用
Nebulized ipratropium bromide is a bronchodilator and is a valuable drug for acute asthma. However, there are also those who hold the opposite view, that this is a hypotonic solution, can cause bronchoconstriction, and therefore, formulated into a solution containing isotonic benzyl chloride ammonium chloride and EDTA (isotonic) solution. The purpose of this study was to compare the efficacy of two solutions of preservative-containing ipratropium bromide (PCIB) and preservative-free ipratropium bromide (PFIB). Methods A total of 33 asthmatic children (21 males) were selected, with an average age of 11.4 years old. All children were familiar with the operation spirometry. One-second forced expiratory volume (FEV_1) improvement of 15% or more after inhaled bronchodilator, at least in the previous 12 months. 28 children inhaled steroids, 3 inhaled cromolyn and / or 4 oral steroids. They used various beta-agonists, theophylline and ipratropium bromide regularly or when necessary. Pulmonary function tests were performed two days prior to discontinuation of beta-agonists and anticholinergic drugs for at least 4 hours or theophylline for 12 hours prior to the study. Obstructive forced expiratory volume (FEV 1) and forced expiratory volume (FFE 25-75) between 25 and 75% of forced expiratory volume were obtained with a Gould water-filled respirometer and used