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目的探讨中药利咽雾化液治疗小儿急慢性咽炎的临床疗效及作用机理。方法小儿急性咽炎156例,慢性咽炎78例,随机分为利咽雾化液治疗组和原剂型利咽饮对照组,对比观察两组治疗前后主要症状、体征,并进行药理和药效学动物实验。结果治疗组与对照组临床总有效率分别为急性咽炎98.8%和82.9%,慢性咽炎97.7%和91.4%,治疗组均明显优于对照组(P<0.05)。实验研究表明,利咽雾化液具有抗炎抑菌作用,且安全性高。结论利咽雾化液治疗小儿急慢性咽炎疗效显著,安全可靠,抗炎抑菌作用明显,且无不良反应。
Objective To investigate the clinical efficacy and mechanism of Liyan nebulizer for treating acute and chronic pharyngitis in children. Methods 156 cases of acute pharyngitis in children and 78 cases of chronic pharyngitis were randomly divided into the Liyan nebulized liquid treatment group and the original dosage Liyan drink control group. The main symptoms and signs before and after treatment were observed and compared. The pharmacological and pharmacodynamic animals experiment. Results The total clinical effective rates of the treatment group and the control group were 98.8% and 82.9% for acute pharyngitis and 97.7% and 91.4% for chronic pharyngitis respectively, which were significantly better in the treatment group than those in the control group (P <0.05). Experimental studies have shown that Li Yan aerosol anti-inflammatory and anti-bacterial effect, and high safety. Conclusion Liyan nebulized liquid treatment of children with acute and chronic pharyngitis significant effect, safe, reliable, anti-inflammatory and anti-bacterial effect, and no adverse reactions.