论文部分内容阅读
目的:考察阿霉素与 4种常用输液配伍后的稳定性 ,为临床安全用药提供依据。 方法 :采用紫外分光光度法在 2 33nm处测定阿霉素的含量 ,对阿霉素在 4种输液中的溶解速度、热稳定性、光稳定性进行考察。结果 :阿霉素在注射用水中溶解速度最快 ,在 5 0 g/ L 葡萄糖注射液中次之 ,在 5 0 g/ L 葡萄糖氯化钠注射液和 9g/ L 氯化钠注射液中溶解速度较慢 ;阿霉素在输液中的热稳定性较好 ,80℃ 4h内除 9g/ L 氯化钠注射液中的含量降低10 %左右和颜色稍淡外 ,其它输液均无变化 ;室温漫射光对其影响很小 ,10 h内含量、外观、p H值基本无变化 ;但日照对其稳定性影响很大 ,10 min含量即下降 10 %左右 ,溶液颜色也逐渐变淡。结论 :阿霉素可与 4种输液配伍 ,应先用少量注射用水溶解后 ,加入其它 3种输液中混匀静推或静滴 ,操作中应避免阳光直射。
Objective: To investigate the stability of doxorubicin after compatibility with 4 kinds of common transfusion, to provide basis for clinical safety medication. Methods: The content of doxorubicin was determined at 2 33 nm by UV spectrophotometry. The dissolution rate, thermal stability and light stability of doxorubicin in 4 kinds of infusions were investigated. Results: Doxorubicin dissolved most rapidly in water for injection, followed by 50 g / L glucose injection, dissolved in 50 g / L glucose sodium chloride injection and 9 g / L sodium chloride injection Adriamycin in the transfusion in the thermal stability is better, 80 ℃ 4h 9g / L sodium chloride injection in addition to the content of about 10% and slightly lighter, no other infusions; room temperature The diffused light had little effect on the contents, appearance and p H values within 10 h. However, the sunshine had a great influence on the stability, and the content of 10 min decreased about 10%, and the color of the solution gradually fades. CONCLUSION: Doxorubicin can be compatible with 4 kinds of infusions. After it is dissolved in a small amount of water for injection, it is added into the other 3 kinds of infusions and mixed with static push or intravenous drip. In operation, direct sunlight should be avoided.