论文部分内容阅读
目的探讨血浆偶联因子6(CF6)水平在急性冠脉综合征(ACS)患者中的变化以及与病情严重程度、预后的关系。方法随机入选非ST段抬高型急性冠脉综合征(NSTEACS)患者148例及ST段抬高型急性冠脉综合征(STEACS)患者40例,于入院次日清晨抽取空腹肘静脉血用放免法测定血浆CF6水平,分析NSTEACS及STEACS患者的血浆CF6水平的变化及与TIMI危险积分的关系,随访观察血浆CF6水平与预后的关系。结果NSTEACS及STEACS患者血浆CF6水平较健康对照明显升高(P<0.05),NSTEACS患者血浆CF6水平随着TIMI危险积分的升高而升高(P<0.05),STEACS患者血浆CF6水平随着Killip心功能分级的升高而升高(P<0.05),随着血浆CF6水平的升高,ACS患者的主要心血管不良事件有增加的趋势。结论CF6参与了ACS的病理生理过程,并与患者的病情严重程度呈正相关,CF6水平升高提示患者预后不良。
Objective To investigate the changes of plasma concentration of coupling factor 6 (CF6) in patients with acute coronary syndrome (ACS) and its relationship with the severity and prognosis. Methods A total of 148 patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) and 40 patients with ST-segment elevation acute coronary syndrome (STEACS) were enrolled in the study. Fasting elbow venous blood The levels of plasma CF6 in patients with NSTEACS and STEACS were analyzed. The changes of plasma CF6 levels and the relationship with TIMI risk score were analyzed. The relationship between the levels of CF6 and prognosis was followed up. Results The levels of plasma CF6 in patients with NSTEACS and STEACS were significantly higher than those in healthy controls (P <0.05). The levels of CF6 in patients with NSTEACS increased with the increase of TIMI risk score (P <0.05) Cardiac function grade increased and increased (P <0.05). With the increase of plasma CF6 level, the main cardiovascular adverse events in ACS patients tended to increase. Conclusion CF6 participates in the pathophysiological process of ACS and is positively correlated with the severity of the disease. The elevated CF6 level indicates that the prognosis is poor.