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阿朴脂蛋白E的遗传多态性受阿朴E结构基因上三个等位基因ε2、ε3、ε4控制。作者检测了心肌梗塞患者的遗传性阿朴脂蛋白E及其异型E_2、E_3及E_4的频率,以证实这些基因使患者发生动脉粥样硬化的遗传风险。作者选择523名心肌梗塞患者,分别测定其血浆胆固醇、甘油三酯、阿朴B和E,并与对照组进行比较。结果表明,心肌梗塞患者阿朴E_4异型的频率明显偏低(0.05>p>0.025)。而E_2纯合子和杂合子的频率则无显著增加。
Apolipoprotein E genetic polymorphism is controlled by three alleles ε2, ε3, ε4 on ApoE structural gene. The authors examined the genetic apolipoprotein E and its isoforms E_2, E_3 and E_4 in patients with myocardial infarction to determine the genetic risk of these genes in patients with atherosclerosis. The authors selected 523 patients with myocardial infarction, were measured in plasma cholesterol, triglycerides, A Park B and E, and compared with the control group. The results showed that the frequency of Apo E_4 isotype was significantly lower in patients with myocardial infarction (0.05> p> 0.025). However, there was no significant increase in the frequencies of E_2 homozygotes and heterozygotes.