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采用卵胞质内圆形精子细胞注射 (roundspermatidinjection ,ROSI)或长形精子细胞注射 (elongatedspermatidin jection ,ELSI)技术治疗完全不能产生精子的非梗阻性无精子症 (NOA)病人已获成功 ,精子细胞可从病人精液或从睾丸活检组织中获取。但精子细胞的受精率和妊娠率令人失望 ,限制这项技术成功和阻碍其临床应用的许多问题仍然没有解决 ,包括精子细胞的核蛋白不完全成熟、卵子激活不足及如何正确选择存活精子细胞等
Non-obstructive azoospermia (NOA) patients have been successfully treated with roundspermatidinjection (ROSI) or elongated spermatidin jection (ELSI), and sperm cells can be Acquired from the patient’s semen or from the testis biopsies. However, the fertilization rate and pregnancy rate of sperm cells are disappointing. Many problems that limit the success of this technology and hinder its clinical application are still unsolved. These include incomplete maturation of nuclear proteins of sperm cells, insufficient activation of oocytes and selection of surviving sperm cells Wait