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在输液制剂的制备和使用中,药剂人员和医生都要考虑渗透压的问题。对于此类制剂的渗透压应如何要求呢?这不能简单地说成必须是等渗溶液,而是要根据病人的具体情况来决定。配制每种输液制剂都要准确无误地加以计算,否则就会达不到治疗目的或者给病人带来不良后果。本文简单介绍一下输液制剂渗透压的具体计算问题,特别是渗透压与当量浓度的关系。渗透压和当量浓度的关系药剂人员计算制剂的渗透压多用冰点下降法或氯化钠等渗当量法,而目前临床上多用渗透克分子量(简称渗量,Osm)来计算渗透压。渗量的计算如下:单价离子,每当量具有1渗量的压力(例如钠
In the preparation and use of infusion preparations, both the practitioner and the doctor consider the problem of osmotic pressure. How is the osmotic pressure required for such preparations? This can not be said simply as an isotonic solution, but rather it depends on the patient’s specific circumstances. The preparation of each infusion formulation should be calculated accurately, otherwise it will not achieve the purpose of treatment or to patients with adverse consequences. This article briefly describes the specific calculation of the transfusion pressure osmotic pressure, especially the relationship between osmotic pressure and equivalent concentration. The relationship between osmotic pressure and equivalent concentration Pharmacists calculate the osmotic pressure of the preparation more freezing point method or sodium chloride isotonic equivalent method, and currently the clinical use of osmotic molecular weight (referred to as osmosis, Osm) to calculate the osmotic pressure. The infiltration is calculated as follows: Monovalent ions, each equivalent of a permeate pressure (such as sodium