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目的:探讨右美托咪定对慢性阻塞性肺疾病急性加重期(AECOPD)患者机械通气的镇静效果和安全性。方法:选取2012年6月-2014年9月在我院接受气管插管呼吸机辅助通气治疗的AECOPD患者62例,并将其随机分为实验组和对照组。其中,对照组患者给予常规治疗,实验组在常规治疗的基础上给予右美托咪镇痛。观察和比较两组患者机械通气持续时间、ICU停住时间、呼吸机相关性肺炎(VAP)、心动过缓和谵妄的发生率。结果:实验组患者机械通气时间及ICU停住时间均明显短于对照组,VAP、心动过缓及谵妄的发生率均显著低于对照组,差异均具有统计学意义(P<0.05)。结论:右美托咪定对行机械通气慢性阻塞性肺疾病急性加重期患者良好的镇静效果,且安全性高,值得临床推广。
Objective: To investigate the sedative effect and safety of dexmedetomidine on mechanical ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: Sixty-two patients with AECOPD receiving tracheal intubation and ventilator assisted ventilation in our hospital from June 2012 to September 2014 were selected and randomly divided into experimental group and control group. Among them, the control group of patients given conventional treatment, the experimental group on the basis of conventional treatment given dexmedetomidine analgesia. The duration of mechanical ventilation, duration of ICU stay, ventilator-associated pneumonia (VAP), bradycardia and delirium were observed and compared between the two groups. Results: The duration of mechanical ventilation and ICU stay in experimental group were significantly shorter than those in control group. The incidence of VAP, bradycardia and delirium were significantly lower than those in control group (P <0.05). Conclusion: Dexmedetomidine has a good sedative effect on patients with acute exacerbations of mechanical ventilation and chronic obstructive pulmonary disease, and is safe and worthy of clinical promotion.