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目的了解我国甲型H1N1流感患者的临床表现及相关实验室检查和治疗情况。方法采用描述性流行病学方法对医院2009年10月25日-12月20日收治的34例确诊甲型H1N1流感患者的临床资料进行回顾性分析。结果 34例患者临床以轻症为主,重症患者仅1例;主要症状为发热34例(100.0%),最高体温平均(38.8±0.68)℃,咳嗽27例(79.4%),咽痛22例(64.7%),咳痰15例(44.1%),全身酸痛13例(38.2%),头痛12例(35.3%),乏力8例(23.5%),流涕8例(23.5%);主要体征为咽部充血30例(88.2%),扁桃体肿大15例(44.1%);实验室检查外周血白细胞总数正常32例(94.1%),降低2例(5.9%),中性粒细胞分类升高14例(41.2%),淋巴细胞分类降低12例(35.3%),58.8%的患者血清C-反应蛋白不同程度升高;国产奥司他韦治疗24h内,>80.0%的患者体温恢复正常,临床症状和体征明显改善,未发现明显不良反应。结论 34例确诊甲型H1N1流感患者外周血白细胞总数正常,中性粒细胞分类升高,近60.0%的患者血清C-反应蛋白增高,可能是有别于其他季节性流感的临床特征;国产奥司他韦治疗安全、有效。
Objective To understand the clinical manifestations and laboratory tests and treatment of Influenza A (H1N1) in our country. Methods Descriptive epidemiological methods were used to retrospectively analyze the clinical data of 34 confirmed cases of Influenza A (H1N1) from October 25 to December 20, 2009 in the hospital. Results The main clinical symptoms were 34 cases (100.0%), the highest body temperature (38.8 ± 0.68) ℃, 27 cases (79.4%) of cough, 22 cases of sore throat (64.7%), sputum 15 (44.1%), systemic pain 13 (38.2%), headache 12 (35.3%), fatigue 8 (23.5%) and runny nose 8 There were 30 cases (88.2%) with pharyngeal hyperemia and 15 cases (44.1%) with tonsil enlargement. The total number of peripheral blood leukocytes in laboratory was 32 cases (94.1%), 2 cases (5.9% The serum levels of C-reactive protein increased in 14 cases (41.2%), 12 cases (35.3%), and 58.8%, respectively. The body temperature returned to normal in> 80.0% of patients treated with domestic oseltamivir , Clinical symptoms and signs improved significantly, no significant adverse reactions were found. Conclusion The total number of peripheral white blood cells in 34 patients with confirmed type A H1N1 influenza is normal and the classification of neutrophils is increased. Serum C-reactive protein is increased in 60.0% of the patients, which may be different from the clinical features of other seasonal influenza. Stavanger treatment is safe and effective.