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目的研究手性分子与核磁共振(NMR)谱图之间的关系,为手性化合物研究提供参考。方法通过举例分析,阐述手性分子与NMR谱图之间的关系。如毗邻一个手性中心的亚甲基中的2个质子化学位移并非等价,—CH_2—基团实际上是—CH_aH_b—结构。此方法可以用来确定ee%(对映体过量)值。结果给出了应用手性衍生试剂、手性溶剂化试剂和手性位移试剂来确定ee%值的方法;此外,对手性螺环化合物的~1 H NMR谱图也进行了讨论。结论对于手性分子与NMR谱图之间关系的研究,可为通过NMR谱图表征手性分子提供参考。
Objective To study the relationship between chiral molecules and nuclear magnetic resonance (NMR) spectra and to provide references for the study of chiral compounds. Methods By way of an example analysis, the relationship between the chiral molecules and the NMR spectra is illustrated. For example, the two proton chemical shifts in the methylene adjacent to a chiral center are not equivalent and the -CH 2 - group is actually a -CH_aH_b- structure. This method can be used to determine the ee% (enantiomeric excess) value. Results are given for the determination of ee% using chiral derivatisation reagents, chiral solvating reagents and chiral shift reagents. In addition, ~ H NMR spectra of chiral spiro compounds are also discussed. Conclusion The study on the relationship between chiral molecules and NMR spectra can provide a reference for the characterization of chiral molecules by NMR spectroscopy.