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目的:分析孕期个体化补充叶酸对于胎儿神经管缺陷的预防作用。方法:选取惠州市中心人民医院2015年3月至2016年4月接收的120例孕产妇,结合临床随机表法将其平均地列入观察组与对照组,对照组采用传统补充叶酸法与观察组采用个体化补充叶酸法,对比两组孕妇叶酸和血浆同型半胱氨酸(Hcy)浓度以及胎儿神经管缺陷的发生率。结果:治疗后,两组叶酸浓度和血浆Hcy水平比较,治疗后,观察组的Hcy水平(9.8±2.5)μmol/L,叶酸浓度为(6.8±1.4)μg/L,对照组的Hcy水平(7.9±1.9)μmol/L,叶酸浓度(8.4±2.2)μg/L,观察组显著高于对照组,差异具有统计学意义(P<0.05)。观察组胎儿神经管缺陷的发病率是5.0%,对照组为18.3%,观察组胎儿神经管缺陷的发生率明显较对照组低,差异具有统计学意义(P<0.05)。结论:孕期个体化补充叶酸能够有效地降低胎儿神经管缺陷的发生率。
Objective: To analyze the preventive effect of individualized folic acid supplement during pregnancy on neural tube defects in fetus. Methods: A total of 120 pregnant women received by Huizhou Central People’s Hospital from March 2015 to April 2016 were enrolled in the observation group and the control group according to the randomized clinical trial. The control group was treated with conventional folic acid supplementation and observation Group using individual supplementation folic acid method, compared the two groups of pregnant women folic acid and plasma homocysteine (Hcy) concentration and the incidence of fetal neural tube defects. Results: After treatment, the Hcy levels in the two groups were 9.8 ± 2.5 μmol / L and folic acid was 6.8 ± 1.4 μg / L after treatment, while the levels of Hcy in the control group 7.9 ± 1.9) μmol / L and folic acid (8.4 ± 2.2) μg / L respectively. The observation group was significantly higher than that of the control group (P <0.05). The incidence of neural tube defects was 5.0% in the observation group and 18.3% in the control group. The incidence of neural tube defects in the observation group was significantly lower than that in the control group (P <0.05). Conclusion: Individualized folic acid during pregnancy can effectively reduce the incidence of fetal neural tube defects.