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目的通过对急性冠状动脉综合征(ACS)患者血清C反应蛋白(CRP)的检测,探讨CRP在ACS中的临床应用。方法采用免疫透射比浊法,检测178例ACS患者血清CRP浓度,其中50例稳定心绞痛(SAP)患者,66例不稳定心绞痛(UAP)患者,62例心肌梗死(AMI)患者;与94例健康对照者血清进行比较。结果健康人血清中存在微量CRP,女性的CRP水平略低于男性,但差异无统计学意义(P>0.05)。SAP组、UAP组、AMI组血清CRP水平逐渐升高,且3组患者CRP水平显著高于对照组,差异有统计学意义(P<0.01)。结论 CRP可作为临床ACS患者有效的监测指标之一,可作为心血管疾病的危险因子。
Objective To investigate the clinical application of CRP in ACS by detecting serum C-reactive protein (CRP) in patients with acute coronary syndrome (ACS). Methods Immunostaining turbidimetry was used to detect CRP levels in 178 patients with ACS, including 50 patients with stable angina pectoris (SAP), 66 patients with unstable angina pectoris (UAP) and 62 patients with myocardial infarction (AMI), and 94 healthy controls Control sera were compared. Results There was a slight amount of CRP in serum of healthy people, while the level of CRP in female was slightly lower than that in men (P> 0.05). Serum CRP levels gradually increased in SAP, UAP and AMI groups, and CRP levels in three groups were significantly higher than those in control group (P <0.01). Conclusion CRP can be used as one of the effective monitoring indicators in clinical ACS patients and can be used as a risk factor for cardiovascular disease.