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分别测定LADA患者45例、2型糖尿病患者40例两组的HbA1c、FPG及2hpG、血清胰岛素、C-肽、胰岛自身抗体和IL-6、TNF-α的水平及体重指数、年龄。结果LADA组与T2DM组间年龄、HbA1c、FPG及2hpG的差异均无统计学意义(P>0.05)。LADA组的体重指数(BMI)(20.3±1.2)kg/m2显著低于T2DM组(23.7±4.3)kg/m2(P<0.01),GAD-65Ab、IA-2Ab均阳性的LADA患者的BMI明显低于1种抗体阳性。结论:对临床貌似T2DM的患者,发病时低BMI、低C-肽可作为筛查LADA的临床线索,确诊LADA需测定胰岛素自身抗体,胰岛自身抗体联检对LADA的诊断具有重要意义。
The levels of HbA1c, FPG and 2hpG, serum insulin, C-peptide, islet autoantibodies and IL-6, TNF-α and body mass index and age in 45 LADA patients and 40 patients with type 2 diabetes mellitus were measured. Results There was no significant difference in age, HbA1c, FPG and 2hpG between LADA group and T2DM group (P> 0.05). The body mass index (BMI) in LADA group (20.3 ± 1.2) kg / m2 was significantly lower than that in T2DM group (23.7 ± 4.3) kg / m2 (P <0.01). The BMI was significantly higher in LADA patients with positive GAD-65Ab and IA- Less than 1 antibody positive. CONCLUSIONS: Low BMI and low C-peptide levels can be used as clinical clues in the screening of LADA in patients with clinically T2DM. It is of great significance to diagnose LADA by confirming LADA with insulin autoantibodies and islet autoantibodies.