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为探讨血清Ⅱ型前胶原(PCⅡ)、透明质酸(HA)和层粘连蛋白(LN)变化与白血病病情的关系,采用放射免疫分析法(RIA)对41例白血病患者血清3项指标进行了动态观察。结果显示,急性白血病(AL)、慢性粒细胞白血病(CML)急变治疗前3项指标血清含量均高于对照组(均P<0.01或0.05),CML慢性期治疗前血清PCⅡ和HA含量高于正常对照组(P<0.01和0.05),AL完全缓解(CR)期血清3项指标含量与治疗前比较均有明显下降(均P<0.05或0.01)。伴或不伴肝大者3项指标血清含量均有明显差异(P<0.05),伴或不伴感染者血清HA含量亦有显著性差异(P<0.01)。3项指标血清水平增高与骨髓白血病细胞百分数呈正相关。提示动态检测血清PCⅡ、HA和LN可以作为考察白血病病情变化状态的一组辅助指标。
To investigate the relationship between serum type II procollagen (PCII), hyaluronic acid (HA), and laminin (LN) changes and leukemic conditions, radioimmunoassay (RIA) was performed on 41 serum leukemia patients. Dynamic observation. The results showed that the serum levels of the three indicators before acute leukemia (AL) and chronic myeloid leukemia (CML) were higher than those of the control group (all P<0.01 or 0.05). The serum levels of PCII and HA before the chronic phase of CML were higher than those before treatment. In the normal control group (P<0.01 and 0.05), the serum levels of the three indicators in the complete remission (CR) phase were significantly lower than before treatment (all P<0.05 or 0.01). The serum levels of the three indicators with or without hepatomegaly were significantly different (P<0.05), and the serum HA levels in the patients with or without infection also had significant differences (P<0.01). The increase of serum levels of the three indicators was positively correlated with the percentage of bone marrow leukemia cells. Tips The dynamic detection of serum PCII, HA, and LN can be used as a set of auxiliary indicators to examine the changing state of leukemia.