目的探讨卵巢成熟畸胎瘤(MCT)患者肿瘤直径和血清CA125、CA199在不同年龄组的临床特点。方法回顾性分析2012年5月-2014年5月在中山大学附属中山医院妇产科因MCT行手术治疗患者的临床资料,根据患者年龄分为5组:<20岁29例,20~29岁121例,30~39岁76例,40~49岁55例,≥50岁20例,并进行对比分析。结果共纳入301例患者,MCT平均直径大小以<20岁组最大,其次是≥50岁组,30~39岁组最小,差异有统计学意义(P<0.05);血清CA199平均水平以<20岁和≥50岁组最高,以30~39岁组和40~49岁组最低,差异有统计学意义(P<0.05),而CA125平均水平在5个年龄组中的差异无统计学意义(P>0.05)。此外,CA199阳性率在5组间比较呈下降趋势,差异有统计学意义(P<0.05),而CA125阳性率在5组间比较,差异无统计学意义(P>0.05)。结论绝大多数患者发现MCT的年龄阶段位于20~49岁之间。不同年龄阶段MCT直径大小、CA199水平分布有所不同,这将有助于临床更好地理解和诊断MCT。 Objective To investigate the clinical features of tumor diameter and serum CA125, CA199 in different age groups in patients with mature ovarian teratoma (MCT). Methods The clinical data of patients with obstetrics and gynecology at Zhongshan Hospital Affiliated to Sun Yat-sen University from May 2012 to May 2014 were retrospectively analyzed. The patients were divided into 5 groups according to the age of the patients: <20 years old 29 cases, 20-29 years old 121 cases, 30 to 39 years old in 76 cases, 40 to 49 years in 55 cases, ≥ 50 years in 20 cases, and comparative analysis. Results A total of 301 patients were enrolled. The average size of MCT was the largest in the group of <20 years old, followed by the group of> 50 years old and the smallest in the group of 30-39 years old (P <0.05). The average serum CA199 level was <20 (P <0.05), while the average level of CA125 was not significantly different between the five age groups (P <0.05) P> 0.05). In addition, the positive rate of CA199 in the five groups showed a downward trend, the difference was statistically significant (P <0.05), while the CA125 positive rate in the five groups, the difference was not statistically significant (P> 0.05). Conclusion The vast majority of patients found that the age of MCT in the 20 to 49 years old. Different age groups MCT diameter size, CA199 horizontal distribution of different, which will help clinical better understanding and diagnosis of MCT.