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用标准的微量淋巴细胞毒试验、62种人白细胞抗原(HLA)抗血清调查了61例弥漫性甲状腺肿伴甲状腺机能亢进症(Graves病)病人的HLA-A、HLA-B和HLA-Cw抗原.Graves病组的HLA-Bw_(46)抗原发生率(49.18%)显著高于对照组(5.31%),相对危险率(RR)为17.903,相对危险率的显著性x~2值为19.240(P<0.0001).
HLA-A, HLA-B and HLA-Cw antigens were investigated in 61 patients with Graves’ disease of diffuse goiter with 62 human leukocyte antigen (HLA) antisera using a standard microlymphocytotoxicity test . The incidence of HLA-Bw_ (46) antigen (49.18%) in Graves disease group was significantly higher than that in control group (5.31%), the relative risk (RR) was 17.903, and the relative risk ratio was 19.240 P <0.0001).