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目的:探讨来曲唑用于排卵障碍患者促排卵治疗的效果。方法:选择2009年9月～2010年4月来我生殖中心就诊的排卵障碍患不孕患者123例,随机分为来曲唑组、来曲唑+尿促性腺激素(human menopausal gonadotropin,HMG)组、HMG3个组。分别比较三组的未破裂卵泡黄素化综合征(luteinized unrup tured follicle syndrome,LUFS)、多胎妊娠、卵巢过度刺激综合征(ovarian hyperstimulationsyndrome,OHSS)发生率。结果:各组间周期妊娠率、未破裂卵泡黄素化综合征、卵巢过度刺激综合征发生率、多胎妊娠率均有显著差异(P<0.05)。结论:单用来曲唑对排卵障碍有较高的妊娠率,较低的未破裂卵泡黄素化综合征、卵巢过度刺激综合征发生及多胎风险。
Objective: To investigate the effect of letrozole on ovulation induction in patients with ovulation disorders. Methods 123 cases of infertility patients with ovulation disorder who visited our reproductive center from September 2009 to April 2010 were randomly divided into three groups: letrozole group, letrozole + HMG (gonadotropin) Group, HMG3 group. The incidences of luteinized unrup tured follicle syndrome (LUFS), multiple pregnancy and ovarian hyperstimulation syndrome (OHSS) were compared between the three groups. Results: There was a significant difference in cycle pregnancy rate, luteinizing unruptured follicle syndrome, ovarian hyperstimulation syndrome and multiple pregnancy rate (P <0.05). CONCLUSIONS: Letrozole alone has a higher pregnancy rate for ovulation disorders, a lower luteinizing unruptured follicle syndrome, an ovarian hyperstimulation syndrome, and a multiple birth risk.