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采用同位素示踪法，以~３Ｈ－盐酸小檗碱作为示踪物，研究前列安栓在大鼠体内的吸收及分布。结果表明：药物自直肠吸收迅速，药后５分钟即可从血中测到放射性，并迅速到达靶器官（前列腺），药后５分钟即可从前列腺中测到放射性，且药物放射性在前列腺中的富集浓度高于其它器官（直肠、肝、肾除外），至２４小时仍维持一定水平，这对前列腺炎及前列腺增生的治疗有特殊意义；此外，药物放射性在肝、肾中的水平明显高于其他器官，表明这两个器官可能是该药代谢和排泄的主要场所。
Using isotope tracer method, ~3H-berberine hydrochloride was used as a tracer to study the absorption and distribution of Qianliean suppository in rats. The results showed that the drug was rapidly absorbed from the rectum, and radioactivity was detected from the blood within 5 minutes after the drug and quickly reached the target organ (prostate). Radioactivity was detected from the prostate within 5 minutes after the drug was administered, and the drug radioactivity was in the prostate. The concentration of enrichment is higher than other organs (excluding the rectum, liver, and kidneys), and maintains a certain level up to 24 hours, which has special significance for the treatment of prostatitis and benign prostatic hyperplasia; In addition, the level of drug radioactivity in the liver and kidney is significantly Higher than other organs, indicating that these two organs may be the main site of metabolism and excretion of the drug.