Objective To recommend an index named glucose safety control index (GSCI) to evaluate the efficacy and safety for insulin regimens.Data sources We searched databases for primary studies published in English.The main search concepts were type 2 diabetes,insulin treatment,premixed insulin,premixed insulin analogs,basal inuslin,basal inuslin analogs,bolus insulin,bolus insulin analogs,safety and efficacy.Study selection Studies were eligible for inclusion if they met all of the following criteria:(1) type 2 diabetic patients aged ＞18 years were included; (2) random control studies with at least 12 weeks of follow-up; (3) different insulin regimens were evaluated.Results When long-acting basal insulin therapy compared with neutral protamine Haged (NPH) insulin therapy,the proportion of GSCI％A1c ratio more than 1 was 100％,the proportion of GSCIΔA1c ratio more than 1 was 94.44％.When premixed insulin therapy compared with oral hypoglycemic agents plus basal insulin therapy,the proportion of GSCI％A1c ratio more than 1 was 45.5％,the proportion of GSCIΔA1c ratio more than 1 was 38.9％.When premixed insulin therapy compared with oral hypoglycemic agents,the proportion of GSCI％A1c ratio less than 1 was 100％,the proportion of GSCI△A1c ratio more than 1 was 50％.When premixed insulin therapy compared with basal-bolus insulin therapy,the proportion of GSCI％A1c ratio more than 1 was 37.5％,the proportion of GSCIΔA1c ratio more than 1 was 50％.Conclusion According to the GSCI ratio,long-acting basal insulin therapy tended to be superior to NPH therapy,oral hypoglycemic agents plus basal insulin therapy tended to be superior to premixed insulin therapy,noninsulin antidiabetic agents and premixed insulin therapy was comparable,and basal-bolus insulin therapy tended to be superior to premixed insulin therapy in type 2 diabetes.