阿昔洛韦(acyclovir)为广用的抗病毒药物。由于其口服的生物利用度不高,必须静注或高剂量口服应用,才能达到抑制病毒的血浓度,临床应用不利。为了制成前药,曾试以18种氨基酸与其制成酯,发现其中缬氨酸酯最为理想。缬氨酸伐昔洛韦(valacyclovir)近来已批准可应用于治疗免疫功能? Acyclovir is a widely used antiviral drug. Because of its low oral bioavailability, it must be intravenous or high-dose oral application, in order to achieve the blood concentration of the virus inhibition, adverse clinical application. In order to make prodrugs, 18 kinds of amino acids were tried to make esters with them, and the valine ester was found to be most ideal. Valacyclovir has recently been approved for the treatment of immune function?