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目的探讨血液透析联合硝苯地平控释片治疗对顽固性肾性高血压患者血压及肾功能的影响。方法选取2015年1月至2015年12月广东省潮州市饶平县中医(华侨)医院80例顽固性肾性高血压患者,按随机数字法分为对照组(血液透析)和观察组(血液透析联合硝苯地平控释片),每组40例,均连续治疗8周。比较两组患者治疗前后血压变化情况、肾功能变化情况及治疗期间不良反应。结果与对照组比较,观察组治疗后收缩压和舒张压均明显降低,差异有统计学意义(P<0.05);观察组治疗后24 h尿蛋白、血肌酐、血尿素氮较对照组明显降低,差异有统计学意义(P<0.05);与对照组相比,观察组不良反应发生率为5.0%,低于对照组20.0%(P<0.05)。结论血液透析联合硝苯地平控释片治疗顽固性肾性高血压,不仅能够有效控制血压水平、明显改善肾功能,还可降低不良反应发生率,具有较高的治疗安全性。
Objective To investigate the effect of hemodialysis combined with nifedipine controlled release on blood pressure and renal function in patients with refractory renal hypertension. Methods From January 2015 to December 2015, 80 patients with refractory renal hypertension in Raoping County Chinese Medicine (Overseas Chinese) Hospital of Chaozhou City, Guangdong Province were randomly divided into control group (hemodialysis group) and observation group (blood Dialysis nifedipine controlled release tablets), 40 cases in each group, were treated for 8 weeks. The changes of blood pressure, changes of renal function and adverse reactions during treatment were compared between the two groups before and after treatment. Results Compared with the control group, systolic blood pressure and diastolic blood pressure in the observation group were significantly decreased after treatment (P <0.05), and the levels of urinary protein, serum creatinine and blood urea nitrogen in the observation group were significantly lower than those in the control group , The difference was statistically significant (P <0.05). Compared with the control group, the adverse reaction rate in the observation group was 5.0%, which was lower than that in the control group (20.0%, P <0.05). Conclusion Hemodialysis combined with nifedipine controlled release tablets in the treatment of refractory renal hypertension not only can effectively control blood pressure levels, significantly improve renal function, but also reduce the incidence of adverse reactions, with high safety of treatment.