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胃癌的发生、侵袭和转移涉及多条信号传导通路和复杂的分子作用机制,众多的研究集中于激活相关信号通路的上游分子上。Cyr61(cysteine-rich61,高半胱氨酸蛋白61)是即刻早期基因产物之一,为一种富含半胱氨酸的可与肝素、整合素结合的分泌性蛋白,可促进细胞增殖、黏附和分化,参与多种生理、病理过程。Cyr61可以通过NF-κB和PI3K/mTOR及MAPK信号通路促进胃癌细胞的侵袭,通过MAPK/ERK信号通路促进胃癌的腹腔种植转移,通过整合素αvβ3/Src/PI3K/Akt依赖的信号通路促进胃癌细胞的趋化性及跨血管内皮的迁移能力。
The occurrence, invasion and metastasis of gastric cancer involve multiple signal transduction pathways and complex molecular mechanisms of action. Numerous studies have focused on the upstream molecules that activate related signaling pathways. Cyr61 (cysteine-rich61, homocysteine 61) is one of the immediate early gene products, a cysteine-rich, secreted protein that binds heparin and integrin and promotes cell proliferation and adhesion And differentiation, involved in a variety of physiological and pathological processes. Cyr61 can promote the invasion of gastric cancer cells through NF-κB, PI3K / mTOR and MAPK signaling pathways, and promote the peritoneal metastasis of gastric cancer through the MAPK / ERK signaling pathway and promote the growth of gastric cancer cells through the integrin αvβ3 / Src / PI3K / Akt signaling pathway Chemotaxis and migration across the vascular endothelium.