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目的:探讨桂林西瓜霜及碱性成纤维细胞生长因子(bFGF)对宫颈糜烂VEGF蛋白表达的影响。方法:157例Ⅲ度宫颈糜烂患者,随机分为:治疗组用桂林西瓜霜喷敷、对照组用bFGF-胶原蛋白海绵贴敷。应用VEGF免疫组化SP法染色对照观察两组宫颈糜烂组织在治疗前、后VEGF蛋白的表达。结果:治疗前宫颈糜烂组织VEGF蛋白表达,两组间无显著性差异(P>0.05),治疗后两组表达均显著增加,且治疗组高于对照组(P<0.05)。结论:桂林西瓜霜对宫颈糜烂上皮组织VEGF蛋白表达有增强作用。提示其对血管生成,创面修复关系密彻。
Objective: To investigate the effect of watermelon frost and basic fibroblast growth factor (bFGF) on the expression of VEGF in cervical erosion. Methods: 157 patients with grade Ⅲ cervical erosion were randomly divided into: the treatment group was sprayed with watermelon cream Guilin, the control group with bFGF-collagen sponge sticking. The expression of VEGF protein in two groups of cervical erosion before and after treatment was observed by immunohistochemical staining of VEGF. Results: The expression of VEGF protein in cervical erosive tissue before treatment showed no significant difference (P> 0.05). After treatment, the expression of VEGF in both groups was significantly increased, and the treatment group was higher than the control group (P <0.05). Conclusion: Guilin Watermelon Cream can enhance the expression of VEGF protein in cervical erosion epithelial tissue. Tip of its angiogenesis, wound repair in close relations.