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本实验在保持兔胸膜腔完整条件下造成一侧肺血流阻断,另一侧肺血流增加的模型。在此模型上观察改变肺动脉血流量对油酸肺损伤、肺水肿的影响。结果表明,增加一侧肺动脉血流量显著加重油酸肺损伤水肿程度(P<0.05);阻断肺动脉血流显著减轻油酸肺水肿程度(P<0.05),但阻断肺动脉血流不能制止油酸肺损伤的发生。肺内白细胞扣押结果表明,油酸中毒早期(15分钟),白细胞在肺内扣押最多,增加肺动脉血流,显著增加白细胞在损伤肺内的扣押。以上结果提示,改变肺动脉血流状态将显著影响油酸肺水肿程度,但油酸肺损伤的发生不依赖于肺动脉血流存在。
This experiment in maintaining the integrity of the rabbit pleural cavity caused by one side of the pulmonary blood flow blocked, the other side of the pulmonary blood flow increased model. In this model to observe changes in pulmonary blood flow on oleic acid induced lung injury, pulmonary edema. The results showed that the increase of pulmonary blood flow on one side significantly increased the degree of edema of oleic acid-induced lung injury (P <0.05); blocking pulmonary blood flow significantly reduced the degree of oleic acid-induced pulmonary edema (P <0.05) Flow can not stop the occurrence of oleic acidosis. Pulmonary leukocyte sequestration results show that oleic acidosis in the early (15 minutes), leukocytes seized the most in the lungs, increased pulmonary blood flow, significantly increased leukocyte seizure in the lung injury. These results suggest that changing the state of pulmonary artery flow will significantly affect the degree of oleic acidosis, but the occurrence of oleic acid-induced lung injury does not depend on the presence of pulmonary artery blood flow.