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目的观察缬沙坦与螺内酯对心房颤动(简称房颤)射频消融术后复发率的影响。方法将60例接受房颤射频消融术的患者随机分为螺内酯组、缬沙坦组和对照组,每组20例。随访6个月,对比分析三组患者术后6个月的房颤复发率及左房大小的变化。结果三组分别有1、2、7例房颤复发,其中螺内酯组的复发率较对照组低(5%vs35%,P<0.05)。螺内酯组的左房容积减小幅度较对照组大[(14.1±12.5)ml vs(3.2±8.9)ml,P<0.05]。缬沙坦组无类似结果。结论螺内酯可降低消融术后房颤的复发率,明显减小左房容积。
Objective To observe the effect of valsartan and spironolactone on the recurrence rate after radiofrequency ablation of atrial fibrillation (AF). Methods Sixty patients undergoing atrial fibrillation radiofrequency ablation were randomly divided into spironolactone group, valsartan group and control group, with 20 cases in each group. The patients were followed up for 6 months. The recurrence rate of AF and the size of left atrium at 6 months after operation were compared among the three groups. Results There were 1, 2, and 7 cases of atrial fibrillation recurrence in the three groups, respectively. The recurrence rate of spironolactone group was lower than that of the control group (5% vs 35%, P <0.05). Spironolactone group of left atrial volume decreased more than the control group [(14.1 ± 12.5) ml vs (3.2 ± 8.9) ml, P <0.05]. Valsartan group had no similar results. Conclusion Spironolactone can reduce the recurrence rate of atrial fibrillation after ablation and significantly reduce the left atrium volume.