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目的分析脑梗死患者血浆同型半胱氨酸及纤维蛋白原水平对病情进展、预后的作用。方法回顾分析我科2009年1月-2010年4月住院治疗的脑梗死患者136例血浆同型半胱氨酸及纤维蛋白原水平的临床资料。其中起病在6 h～7 d的进展性脑梗死62例设为观察组,另74例为非进展性脑梗死设为对照组。结果观察组血浆同型半胱氨酸浓度较对照组差异有统计学意义(P<0.05);观察组血浆纤维蛋白原浓度与对照组相比较,差异有统计学意义(P<0.05)。观察组患者第3周时神经功能损伤不同时三组血浆同型半胱氨酸、纤维蛋白原浓度与对照组相比较,差异有统计学意义(P<0.05)。结论血浆同型半胱氨酸、纤维蛋白原水平与进展型脑梗死密切相关,浓度增高可影响脑梗死的预后。降低同型半胱氨酸水平,调整纤维蛋白原含量,对预防和治疗脑梗死有积极作用。
Objective To analyze the effect of plasma homocysteine and fibrinogen on the progression and prognosis of patients with cerebral infarction. Methods The clinical data of 136 patients with plasma homocysteine and fibrinogen in hospitalized patients with cerebral infarction from January 2009 to April 2010 were retrospectively analyzed. Among them, 62 cases of progressive cerebral infarction with onset from 6 h to 7 d were treated as observation group and 74 as non-progressive cerebral infarction as control group. Results The plasma homocysteine concentration in the observation group was significantly lower than that in the control group (P <0.05). The plasma fibrinogen concentration in the observation group was significantly lower than that in the control group (P <0.05). At the third week after operation, the levels of plasma homocysteine and fibrinogen in the observation group were significantly different from those in the control group (P <0.05). Conclusions Plasma homocysteine and fibrinogen levels are closely related to progressive cerebral infarction. Increasing concentrations may affect the prognosis of cerebral infarction. Reduce homocysteine levels, adjust the content of fibrinogen, the prevention and treatment of cerebral infarction have a positive effect.