多甘醇二胺是合成穴醚以及其它含氮大环聚醚等的重要原料。其合成方法常用盖柏瑞尔(Gabriel)法,借α,ω-多甘醇二氯(或溴)醚和邻苯二甲酰亚胺钾盐缩合,继用98％的肼或50％的水合肼还原而制得。用此法时往往因还原和酸解的条件变化而影响收率。自Boyer以LiAlH_4还原有机叠氮化合物的方法合成伯胺以来,Fleischer等报导了用一元醇的甲磺酸酯与叠氮钠反应生成叠氮化合物,再用L_1AlH_4还 Polyglycol diamine is an important raw material for synthetic valence ethers and other nitrogen-containing macrocyclic polyethers. The synthesis method commonly used Gabriel method, α, ω-polyglycol dichloride (or bromine) ether and potassium phthalimide condensation, followed by 98% hydrazine or 50% of Hydrazine reduction and prepared. With this method often due to the reduction and acid hydrolysis conditions affect the yield. Since Boyer synthesizes primary amines by the reduction of organic azides with LiAlH 4, Fleischer et al. Reported that the mesylate of monohydric alcohols reacted with sodium azide to form azides and then L_1AlH 4