目的:探讨当归承气汤对躁狂症患者生活质量的影响。方法:应用随机、双盲、病例对照研究方法,将123例患者随机分成当归承气汤组41例、碳酸锂组42例和当归承气汤合并碳酸锂组40例,分别使用当归承气汤、碳酸锂、当归承气汤合并碳酸锂治疗,疗程8周,在基线、2周、4周和8周末时,对Young氏躁狂量表(YMRS)、副反应量表(TESS)及健康状况问卷(SF-36)等进行评定。结果:YMRS评分3组在治疗前与治疗后2周、4周及8周比较差异均有统计学意义(P<0.01);3组之间比较,YMRS总分在治疗2周、4周后当归承气汤组与当归承气汤合并碳酸锂组比较差异有统计学意义(P=0.004、P=0.001),治疗8周后3组之间两两比较差异均有统计学意义(P<0.01)。治疗前后比较当归承气汤组在精神健康(MH)条目评分差异无统计学意义(P>0.05),其余条目量表评分比较差异均有统计学意义(P<0.01),碳酸锂组和当归承气汤合并碳酸锂组在躯体功能(PF)、躯体健康问题导致的角色受限(RP)、躯体疼痛(BP)、总体健康感(GH)、生命活力(VT)、社交功能(SF)、情感问题所致的角色受限(RE)、精神健康(MH)、健康变化自评(HT)、躯体健康总评(PCS)和精神健康总评(MCS)治疗前后差异有统计学意义(P<0.01)。治疗后3组之间两两比较在PF条目评分差异均无统计学意义(P>0.05),RP、GH、SF、MCS量表评分比较差异有统计学意义(P<0.01),BP量表评分比较当归承气汤组与当归承气汤合并碳酸锂组差异有统计学意义(P=0.004),VT、RE、MH、HT、PCS量表评分3组间两两比较差异有统计学意义(P<0.01)。治疗后2、4、8周末TESS总分当归承气汤组显著低于碳酸锂组、当归承气汤合并碳酸锂组,差异有统计学意义(P<0.01)。结论:当归承气汤合并碳酸锂治疗躁狂症可以提高疗效,有效改善躁狂症患者的生活质量,减少不良反应。 Objective: To investigate the effect of Danggui Chengqi Decoction on quality of life in mania patients. Methods: A randomized, double-blind, case-control study, 123 patients were randomly divided into angelica Chengqi soup group of 41 cases, 42 cases of lithium carbonate group and angelica soup with lithium carbonate group of 40 cases, respectively, , Lithium carbonate and Angelica Chengqi Decoction combined with lithium carbonate for 8 weeks. At the end of baseline, 2 weeks, 4 weeks and 8 weeks, Young’s Mania Scale (YMRS), TESS and Health Status Questionnaire (SF-36) and other assessment. Results: There were significant differences in YMRS score between the three groups before treatment and two weeks, four weeks and eight weeks after treatment (P <0.01). The total score of YMRS between the two groups after treatment for 2 weeks and 4 weeks There was significant difference between Angelica Chengqi Decoction group and Angelica Chengqi Decoction combined with lithium carbonate group (P = 0.004, P = 0.001). There was significant difference between the three groups after 8 weeks of treatment (P < 0.01). Before and after treatment, there was no significant difference in the scores of Mental Health (MH) between Danggui Chengqi Decoction group (P> 0.05), and the scores of the rest of the scores were statistically significant difference (P <0.01), lithium carbonate group and Angelica sinensis Chengqi Decoction combined with lithium carbonate showed great improvement in body function (PF), role limitation (RP), somatic pain (BP), general health (GH), vitality and social function (SF) (RE), mental health (MH), HT, PCS and MCS due to emotional problems (P < 0.01). There was no significant difference in scores of PF between two groups after treatment (P> 0.05), and there was significant difference between RP, GH, SF and MCS scales (P <0.01) There was significant difference between the scores of Danggui Chengqi Decoction group and Danggui Chengqi Decoction combined with lithium carbonate group (P = 0.004), and there was significant difference among the three groups in the scores of VT, RE, MH, HT and PCS (P <0.01). The TESS score at 2, 4 and 8 weeks after treatment was significantly lower in the Danggui Chengqi Decoction group than in the lithium carbonate group and the Danggui Chengqi Decoction combined with lithium carbonate group (P <0.01). Conclusion: Angelica Chengqi Decoction combined lithium carbonate treatment of mania can improve the efficacy, effectively improve the quality of life of patients with mania and reduce adverse reactions.