1前言戊菌唑是汽巴—嘉基公司研究开发的一种高效、低毒、广谱的三唑类杀菌剂。它是兼具保护、治疗和铲除作用的内吸性杀菌剂,是甾醇脱甲基化抑制剂,可由作物根、茎、叶等组织吸收并向上传导,经室内活性测定和田间药效实验结果表明,其对葡萄白腐病有较好的防治效果。戊菌唑的合成关键在于中间体2-(2,4-二氯苯基)-戊醇的合成,文献以2,4-二氯苯乙腈与溴丙烷为起始原料经过烷基化,酯化和还原得到中间体2- 1 Introduction Penconazole Ciba - Jiaji company research and development of an efficient, low toxicity, broad-spectrum triazole fungicides. It is a systemic fungicide with the functions of protection, treatment and eradication. It is a sterol demethylation inhibitor which can be absorbed by the roots, stems, leaves and other tissues and transmitted upwards. The results of indoor activity measurement and field efficacy test Show that the grape white rot has a better control effect. The key to the synthesis of penconazole lies in the synthesis of the intermediate 2- (2,4-dichlorophenyl) -pentanol. In the literature, 2,4-dichlorophenylacetonitrile and bromopropane are alkylated, Reduction and reduction to give intermediate 2-