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目的:探讨前列腺特异抗原(PSA)和碱性磷酸酶(ALP)联合检测在早期诊断前列腺癌骨转移中的作用及意义。方法:经核素骨显像将98例前列腺癌患者分为骨转移组和非骨转移组,所有患者均检测PSA和ALP,对比分析两组患者PSA和ALP检测结果、阳性率及与骨转移关系,分析二者联合检测与单项检测对前列腺癌骨转移的敏感度与特异度,以及核素骨显像异常放射性浓聚灶分布情况。结果:骨转移组血清PSA和ALP水平均高于非骨转移组,相比均有显著性差异(P<0.05);PSA单项检测结果骨转移组与非骨转移组阳性率相比无显著性差异(P>0.05),ALP相比有显著性差异(P<0.05);且PSA和ALP值随着骨转移分级增加而增加,呈正相关;PSA和ALP联合检测与单项检测敏感度相比有显著性差异(P<0.05),特异度有极显著性差异(P<0.01);核素骨显像检查阳性结果58.2%,且异常放射性浓聚灶多位于胸腰椎部位。结论:PSA和ALP联合检测有助于早期诊断前列腺癌骨转移,可提高其诊断率。
Objective: To investigate the role of combined detection of prostate specific antigen (PSA) and alkaline phosphatase (ALP) in the early diagnosis of prostate cancer with bone metastasis. Methods: 98 patients with prostate cancer were divided into bone metastasis group and non-bone metastasis group by radionuclide bone imaging. PSA and ALP were detected in all patients. PSA and ALP test results, positive rate and bone metastasis were compared between the two groups The sensitivity and specificity of the combined detection and single detection of the two drugs for bone metastasis of prostate cancer were analyzed. The distribution of abnormal radioactive focal lesions of radionuclide bone imaging was analyzed. Results: The serum levels of PSA and ALP in bone metastasis group were significantly higher than those in non-bone metastasis group (P <0.05). There was no significant difference in PSA test results between bone metastasis group and non-bone metastasis group (P> 0.05), ALP was significantly different (P <0.05), and PSA and ALP values increased with the increase of bone metastasis grade, was positively correlated; PSA and ALP combined detection and single detection sensitivity compared with (P <0.05). The specificity was significantly different (P <0.01). The positive results of radionuclide bone imaging were 58.2%, and the abnormal radioactive focus was mostly located in the thoracolumbar vertebra. Conclusion: Combined detection of PSA and ALP can help early diagnosis of bone metastasis of prostate cancer and improve its diagnosis rate.