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目的探讨他汀类药物治疗脑卒中对患者叶酸、维生素B_(12)水平的影响。方法选择2014年8月—2015年8月来周口市郸城县第二人民医院就诊的64例脑卒中患者作为研究对象,随机分为两组,每组32例,对照组给予营养神经、抗凝溶栓常规治疗,观察组在此基础上给予阿托伐他汀治疗,比较两组患者治疗前后叶酸、维生素B_(12)、血浆同型半胱氨酸(Hcy)水平的变化情况及治疗前后神经功能缺损情况。采用SPSS 19.0统计软件进行统计分析,计量资料用均数±标准差(xˉ±s)表示,采用t检验,P<0.05为差异有统计学意义。结果观察组患者出院时、及出院后1个月叶酸和维生素B_(12)水平显著高于治疗前和对照组,差异有统计学意义(P<0.05)。观察组患者出院时及出院后1月时神经功能缺损评分均显著低于对照组,差异有统计学意义(P<0.05)。结论他汀类药物在治疗脑卒中患者过程中可显著提高叶酸和维生素B_(12)水平,改善神经功能缺损情况,对改善脑猝中预后具有积极作用。
Objective To investigate the effect of statins on the folic acid and vitamin B 12 levels in patients with stroke. Methods Sixty-four stroke patients from the Second People’s Hospital of Dancheng County, Zhoukou City from August 2014 to August 2015 were randomly divided into two groups (n = 32 in each group). The control group was given nutrient nerves, The thrombolytic suppository was routinely treated. The observation group was given atorvastatin on this basis. The changes of folic acid, vitamin B 12 and plasma homocysteine (Hcy) levels before and after treatment were compared between the two groups before and after treatment Functional deficiencies. Using SPSS 19.0 statistical software for statistical analysis, measurement data with mean ± standard deviation (x ˉ ± s) said that using t test, P <0.05 was considered statistically significant. Results The levels of folic acid and vitamin B 12 in the observation group were significantly higher than those before treatment and control group at discharge and one month after discharge (P <0.05). The score of neurological deficit in the observation group at discharge and at 1 month after discharge was significantly lower than that in the control group (P <0.05). Conclusions Statins can significantly increase the levels of folic acid and vitamin B 12 in patients with stroke and improve the neurological deficits, which plays a positive role in improving prognosis in patients with stroke.