论文部分内容阅读
在相同条件下,α-萘乙酸分别与二丁基氧化锡、氧化双(三丁基锡)反应,合成了四核簇状二丁基锡α-萘乙酸酯{[n-Bu2Sn(O2CCH2C10H7)]2O}2(1)和一维链状三丁基锡α-萘乙酸酯[n-Bu3Sn(O2CCH2C10H7)]n(2)。经IR、1H和13C NMR、元素分析和X-射线单晶衍射表征结构。1具有核心结构为氧原子桥联锡构筑的Sn2O2四元环,且四元环二聚形成Sn4O4簇状,中间Sn2O2环的中心为整个分子的对称中心。1中,两相邻配合物分子间通过C-H…π作用、形成一维带状结构。配合物2中,锡原子通过羧基双齿桥联、组成一维链状配位聚合物。测试表明:1和2分别在250、175℃以下可以稳定存在;对人癌细胞Colo205、Hep G2、MCF-7、Hela、NCI-H460增殖均有较强的抑制作用,且2的活性高于1。
Under the same conditions, α-naphthaleneacetic acid was reacted with dibutyltin oxide and bis (tributyltin) oxide respectively to synthesize tetranuclear tufted dibutyl tin α-naphthylacetate {[n-Bu2Sn (O2CCH2C10H7)] 2O} 2 (1) and one-dimensional chain-like tributyl tin α-naphthylacetate [n-Bu3Sn (O2CCH2C10H7)] n (2). The structure was characterized by IR, 1H and 13C NMR, elemental analysis and X-ray single crystal diffraction. 1 has a Sn2O2 four-membered ring with a core structure of oxygen atom bridging tin and dimerizes the four-membered ring to form a cluster of Sn4O4. The center of the middle Sn2O2 ring is the symmetrical center of the whole molecule. 1, two adjacent complexes through the role of C-H ... π molecules, forming a one-dimensional band-like structure. In the complex 2, the tin atom is bridged by carboxyl bidentate to form a one-dimensional chain coordination polymer. The results showed that 1 and 2 could stably exist below 250 and 175 ℃, respectively. The inhibitory effects on the proliferation of human cancer cells Colo205, Hep G2, MCF-7, Hela and NCI-H460 were stronger than those of 2 and 2 1.