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目的探讨早期肠内营养治疗对老年重症急性胰腺炎(severe acute pancreatitis,SAP)患者临床预后的影响。方法收集2008年9月—2014年9月本院收治的42例老年SAP患者,随机分为观察组(EN组),采用早期肠内营养,和对照组(PN组),采用完全肠外营养,对两组患者的外周血CRP、血清白蛋白、住院时间、住院费用、并发症发生率、胰周感染率进行统计分析。计数资料使用χ2检验,计量资料以±s表示,使用t检验,P<0.05为差异有统计学意义。结果 EN、PN组患者住院时间分别为(15.5±3.1)、(18.43±2.6)d,住院费用分别为(1.4±1.2)、(2.1±1.5)万元,两组患者住院时间、住院费用比较差异均有统计学意义(均P<0.05)。EN、PN组患者并发症发生率分别为4.55%、30%,胰周感染率分别为4.55%、25%,EN患者并发症发生率、胰周感染率小于PN组。两组患者在外周血CRP、血清白蛋白方面差异均无统计学意义(均P>0.05)。结论早期应用肠内营养治疗缩短疾病病程,减少住院费用,降低并发症发生率。
Objective To investigate the effect of early enteral nutrition therapy on the clinical prognosis of elderly patients with severe acute pancreatitis (SAP). Methods Forty-two elderly SAP patients admitted to our hospital from September 2008 to September 2014 were randomly divided into observation group (EN group), early enteral nutrition group and control group (PN group), and total parenteral nutrition , The two groups of patients with peripheral blood CRP, serum albumin, hospital stay, hospitalization costs, the incidence of complications, pancreatic weeks infection rates were statistically analyzed. Counting data using χ2 test, measurement data to ± s that the use of t test, P <0.05 for the difference was statistically significant. Results The hospitalization time in EN group and PN group were (15.5 ± 3.1) and (18.43 ± 2.6) days respectively, and the hospitalization costs were (1.4 ± 1.2) and (2.1 ± 1.5) million respectively. The hospitalization and hospitalization costs of the two groups were compared The differences were statistically significant (all P <0.05). The incidence of complications in patients with EN and PN were 4.55% and 30% respectively. The rates of peripancreatic infection were 4.55% and 25% respectively. The incidence of complications in EN patients and the rate of pancreatic was lower than that in PN patients. The two groups of patients in the peripheral blood CRP, serum albumin differences were not statistically significant (P> 0.05). Conclusions The early application of enteral nutrition to shorten the course of the disease, reduce hospitalization costs and reduce the incidence of complications.