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目的探讨儿童传染性单核细胞增多症(IM)患者EB病毒抗体检测的临床价值。方法采用酶联免疫吸附法检测167例IM患儿及60例健康儿童EBV-CA-IgM、EBV-CA-IgG,采集EDTA抗凝血标本进行涂片、瑞氏染色、镜检异型淋巴细胞,并进行分析。结果在167例IM患儿中,EBV-CA-IgM抗体阳性率明显高于对照组,差异有统计学意义(P<0.05),外周血异型淋巴细胞>10%比例IM患儿也明显高于对照组,且EBV-CA-IgM和异型淋巴细胞存在相关性(χ2=6.39,P<0.05)。结论 EBV-CA-IgM是早期诊断IM的重要指标,外周血异型淋巴细胞检测是实验室辅助诊断IM的重要方法,EBV-CA-IgM与异型淋巴细胞联合检测可提高IM诊断的准确性,以弥补单独检测所致的漏诊。
Objective To investigate the clinical value of detecting Epstein-Barr virus (EBV) antibody in children with infectious mononucleosis (IM). Methods EBV-CA-IgM and EBV-CA-IgG were detected by enzyme-linked immunosorbent assay in 167 children with IM and 60 healthy children. EDTA anticoagulant samples were collected for smear, Wright staining and microscopic examination of atypical lymphocytes. And analyze. Results The positive rate of EBV-CA-IgM antibody in 167 children with IM was significantly higher than that in control group (P <0.05), and the rate of peripheral blood lymphocyte> 10% IM was significantly higher than that of IM There was a correlation between EBV-CA-IgM and atypical lymphocytes (χ2 = 6.39, P <0.05). Conclusion EBV-CA-IgM is an important indicator of early diagnosis of IM. Peripheral blood lymphocyte test is an important method for laboratory diagnosis of IM. Combined detection of EBV-CA-IgM and atypical lymphocytes can improve the accuracy of IM diagnosis. Misdiagnosis caused by separate testing.