头孢噻肟(cefotaxime)是新开发的第三代头孢菌素类抗生素。具广泛的抗菌谱和杀菌力。对革兰阴性菌的抗菌活性较现有的头孢菌素都强。和第一、二代头孢菌素不同,本品能通过血脑屏障,在感染性脑脊液中的浓度可达血液浓度的10-30％。本文从抗菌作用、药代动力学、临床应用及不良反应等方面,对该药作一简要论述,以期对临床合理使用本品有所帮助。 Cefotaxime is a newly developed third-generation cephalosporin antibiotic. With a wide range of antibacterial spectrum and bactericidal power. Gram-negative bacteria antibacterial activity than the existing cephalosporins are strong. And the first and second generations of cephalosporins different, the goods through the blood-brain barrier, infectious cerebrospinal fluid concentration of up to 10-30% of blood concentration. This article from the antibacterial, pharmacokinetics, clinical applications and adverse reactions, the drug for a brief discussion, with a view to clinical use of this product may be helpful.