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一、历史卵巢能产生雄激素的发现须追溯至30年代.当时观察给雌性大鼠长期注射hCG后卵巢泡膜内膜细胞明显肥大,并充满了假黄体或泡膜黄体.雌性动物可出现雄性化表现.1962年Falck等将卵巢碎片移植至大鼠眼球前房,发现泡膜内膜细胞和次级间质组织是卵巢内产生雄激素的部位.4年后Ryan和Petro及Rice和Sarard应用生化技术最后证实.二、间质细胞的分类卵巢间质细胞位于卵巢皮质及髓质的疏松结缔组织内,起源于卵巢间质内非特异的
First, the history of ovaries can produce androgen found to be traced back to the 30’s when the observation of long-term injection of hCG to female rats ovarian intima significant hypertrophy of the cells and filled with pseudoterminal or foam film luteal female may appear male The performance in 1962 Falck and other ovarian debris transplanted into the anterior chamber of the eye and found that the foam membrane of the endometrial cells and secondary interstitial tissue is ovarian androgen-producing parts of Ryan and Petro 4 years after the application of Rice and Sarard Biochemical technology finally confirmed .Second, the classification of interstitial cells ovarian stromal cells in the ovarian cortex and medulla loose connective tissue, originated in the ovarian stromal non-specific