论文部分内容阅读
腹腔接种多房棘球绦虫原头蚴感染长爪沙鼠２．５月后，用含０．２％丙硫苯咪唑（ＡＢＺ）药饵喂饲连续治疗２月（剂量２４０ｍｇ／ｋｇ／ｄ）．停药２月后剖杀结果：对照组泡球蚴平均湿重６．３±１．９ｇ，治疗组平均湿重０．９±０．２ｇ，明显低于对照组（Ｐ＜０．０１）。病理组织学检查显示治疗组泡球蚴囊泡明显塌陷、破裂、生发膜坏死脱落，原头蚴与子囊大片钙化．透射电镜检查发现生发膜结构完全破坏；残存原头蚴体细胞核膜断裂缺损，常染色质明显减少而异染色质显著增多成四块状；线粒体数目减少且肿胀、裂解；内质网与高尔基体明显肿胀、解聚、胞浆内可见大量球形空泡小体。表明ＡＢＺ对泡球蚴细胞有严重的破坏作用。
Intraperitoneal inoculation of Echinococcus multilplaceal cercariae Infected Meriones unguiculatus 2.5 months later, with 0.2% propranolol (ABZ) bait for continuous treatment of 2 months (dose 240mg / kg / d). After 2 months of drug discontinuation, the results showed that the average wet weight of the control group was 6.3 ± 1.9g and the average wet weight of the treatment group was 0.9 ± 0.2g, which was significantly lower than that of the control group (P <0.01) . Histopathological examination showed that the cysticercus sac in the treatment group collapsed, ruptured, and the germinal vesicles were necrotic and necrotic. Transmission electron microscopy revealed complete destruction of germinal membrane structure; residual protozoae larvae somatic cell nuclear membrane rupture defects, significantly reduced euchromatin and heterochromatin significantly increased into four; mitochondria decreased and swelling, lysis; endoplasmic reticulum and the Golgi apparatus Obvious swelling, depolymerization, a large number of spherical vacuoles visible in the cytoplasm. That ABZ on the cysticercosis cells have a serious disruptive effect.