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消化性溃疡病是一种常见病多发病,治疗用的药物有植物药、生化药、合成药及半合成药等。按照它们的药理作用,大致可分为:抗酸剂、胃分泌抑制剂、粘膜保护剂、促进组织再生剂以及胃肠道解痉剂等。近年来,虽然出现了一些有希望的新药,但临床上仍以沿用一般的抗酸剂和抗胆碱药物为主。目前,最新型的一种抗溃疡药物,即为组胺 H_2受体拮抗剂。兹将近年来国内外抗消化性溃疡药物的发展情况简述如下:目前,国内已生产或试制的新抗溃疡药有:生胃酮(Carbenoxolone Sodium)(Ⅰ)、甲氰咪胍(Cimetidine)(Ⅱ)、血活素(幼牛血精,Solcoseryl)、丙谷胺(Proglumide)(Ⅲ)、尿囊素(Allantoin)(Ⅳ)、红古豆醇酯以及溃疡愈康(Trithiozine)(Ⅴ)等。
Peptic ulcer disease is a common disease frequently used, the treatment of drugs with plant medicine, biochemical drugs, synthetic drugs and semi-synthetic drugs. In accordance with their pharmacological effects, can be broadly divided into: antacids, gastric secretion inhibitors, mucosal protective agent, promote tissue regeneration agent and gastrointestinal antispasmodic agents. In recent years, although there are some promising new drugs, but the clinical still follow the general antacid and anticholinergic drugs. At present, the latest type of anti-ulcer drugs, namely histamine H 2 receptor antagonist. In recent years, the development of anti-peptic ulcer drugs at home and abroad are summarized as follows: At present, new anti-ulcer drugs that have been produced or trial-produced in China include Carbenoxolone Sodium (Ⅰ), Cimetidine ( (Ⅱ), Solcoseryl, Proglumide Ⅲ, Allantoin Ⅳ, cinnamate and Trithiozine (Ⅴ) Wait.