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目的 了解山东省HGV感染状况,探讨HGV感染与HCV或HBV感染的关系。方法 应用酶联免疫吸附试验(ELISA)对1082例病毒性肝炎患者、77例非甲至戊型肝炎患者和361名献血员进行了血清抗-HGV检测。结果 共检出血清抗-HGV阳性者53例,阳性率3.49%。丙型肝炎患者血清抗-HGV阳性率(8.93%)显著高于乙型肝炎患者(3.32%)(χ2=8.80,P<0.01)。慢性肝炎患者血清抗-HGV阳性率(4.82%)显著高于急性肝炎患者(0.79%)(χ2=10.79,P<0.01)。重型肝炎患者血清抗-HGV阳性率(8.00%)显著高于急性肝炎患者(χ2=10.23,P<0.01)。结论 HGV感染可表现为病毒携带状态、亚临床型和不同临床类型,丙型肝炎患者较乙型肝炎患者更易重叠感染HGV,HGV与HCV或HBV重叠感染可能与病情加重和慢性化的形成有关
Objective To understand the status of HGV infection in Shandong Province and to explore the relationship between HGV infection and HCV or HBV infection. Methods Serum anti-HGV was detected in 1082 patients with viral hepatitis, 77 patients with non-A and E hepatitis and 361 blood donors by enzyme linked immunosorbent assay (ELISA). Results A total of 53 serum anti-HGV positive cases were detected, the positive rate was 3.49%. The positive rate of serum anti-HGV in patients with hepatitis C (8.93%) was significantly higher than that in patients with hepatitis B (3.32%) (χ2 = 8.80, P <0.01). The positive rate of serum anti-HGV in patients with chronic hepatitis (4.82%) was significantly higher than that in patients with acute hepatitis (0.79%) (χ2 = 10.79, P <0.01). Serum anti-HGV positive rate (8.00%) in patients with severe hepatitis was significantly higher than that in patients with acute hepatitis (χ2 = 10.23, P <0.01). Conclusions HGV infection can manifest as virus-carrying status, subclinical type and different clinical types. Patients with hepatitis C are more likely to overlap with hepatitis B patients than HGV patients. HGV and HCV or HBV overlap infection may be related to the progression of the disease and the development of chronicity