Objectives: The prevalence and burden of disease of depression necessitates effective and accessible treatment options worldwide.Since April 2016,Japanese national health insurance has covered nurseadministered cognitive behavioral therapy (CBT) for mood disorders.However,empirical support for nurse-led CBT for depression in Asian countries,especially in Japan,is still lacking.This preliminary study aimed to examine the feasibility and acceptability of nurse-led group CBT for Japanese patients with depression.Methods: In this single-arm study,we evaluated the effects of a 6-week group CBT,led by trained nurses,on patients with major depression.The primary outcome was the Beck Depression Inventory-Ⅱ (BDI-Ⅱ).Assessments were conducted at the beginning and end of the intervention.Results: Of 25 participants screened,23 were eligible for the study (of these,three dropped out during the trial but were included in the analysis).Nurse-led group CBT led to significant improvements in the severity of depression (BDI-Ⅱ,P ＜ 0.001).The mean total BDI-Ⅱ score improved from 23.1 (SD =7.56) to 12.4 (SD =8.57),and the pre-to post-effect size was large (Cohen’s d =1.33).After CBT,45％ of the participants were judged to be treatment responders,and 34％ met the remission criteria.Conclusions: Our preliminary findings indicate that 6 weeks of nurse-led group CBT produced a favorable treatment outcome for individuals with major depression in a Japanese clinical setting.The results of this study might encourage more Asian nurses to provide CBT as a part of their nursing practice.Further controlled trials that address the limitations of this study are required.