青霉素 G 是最早发现的抗菌素,由于毒性低,疗效好,目前仍为普遍应用的最受欢迎的抗菌素之一。但青霉素 G 也最容易引起过敏反应,其发生率占所有药物反应中的第一位。据1968年世界卫生组织的调查报告资料,青霉素 G 过敏反应的发生率为0.7～10%,过敏性休克发生率为0.004～0.015%,在用青霉素治疗的病人中每百万人中有15～20人死于青霉素所致的过敏性休克。国内某院调查179例药物过敏中61.6%为抗菌素所引起,其中50%以上由青霉素G引起,在青霉素 G 引起的过敏反应中3.5%为过敏性休克。在青霉素 G 引起的各种过敏反应中以过敏性休克为最重要。下面就有关问题加以讨论。一、青霉素过敏的过敏原青霉素过敏性休克属于第一型变态反应,其抗体 Penicillin G is one of the earliest discovered antibiotics and is still one of the most popular antimicrobials due to its low toxicity and good efficacy. But penicillin G is also the most likely to cause an allergic reaction, the incidence of all drug reactions in the first place. According to the 1968 World Health Organization survey data, the incidence of penicillin G anaphylaxis was 0.7 to 10%, the incidence of anaphylactic shock was 0.004 to 0.015%, in the penicillin-treated patients per million people have 15 ~ 20 people died of allergic shock caused by penicillin. A hospital survey of 179 cases of drug allergy in 61.6% caused by antibiotics, of which more than 50% caused by penicillin G, allergic reactions caused by penicillin G 3.5% of anaphylactic shock. In allergic shock caused by penicillin G allergic shock is the most important. The following issues to be discussed. First, allergic penicillin allergy penicillin allergic shock is the first type of allergy, the antibody